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허지연Ji Yeun Hur

  • 소속 생명과학과
  • 연구실원천관 205호
  • 이메일 hurji@ajou.ac.kr
  • 내선번호2548

관심분야

  • Neuroscience, Alzheimer's disease

학력

  • 2010.05 Karolinska Inst Stockholm 박사

경력

    2022 – 현재  아주대학교 조교수
2019 – 2022  Memorial Sloan Kettering Cancer Center, Senior Research Scientist
2016 – 2019  Memorial Sloan Kettering Cancer Center, Research Associate
2011 – 2016  Memorial Sloan Kettering Cancer Center, Research Fellow
2010 – 2011  Karolinska Institutet, Postdoctoral Fellow

대표논문

  • [논문] 허지연, Gamma-secretase in Alzheimers dissease, EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.54, No.4, pp. 433-446 (4월, 2022)
  • [논문] 허지연, Innate immunity protein IFITM3 in Alzheimer’s disease., DNA AND CELL BIOLOGY, pp. 1351-1355 (11월, 2021)
  • [논문] 허지연, Georgia R. Frost, Alan E. Renton, Alison Goate, Andrew McKenzie, Bianca T. Esposito, Bin Zhang, Chen Ming, Christina Crump, Douglas S. Johnson, Eitan Wong, Eliezer Masliah, Ivy Trinh, Jen Chyong Wang, Julia TCW, Ketherine R. Sadleir, Lei Guo, Marilia Barros, Minghui Wang, Paul Greengard, Pengju Nie, Robert A. Rissman, Robert Vassar, Si Jia Pan, Thomas Li, Xianxiao Zhou, Xianzhong Wu, Yong Kim, Yotam Sagi, Yujia Zhai, Yue-Ming Li, The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer’s disease. , Nature, Vol.586, No.7831, pp. 735-740 (10월, 2020)
  • [논문] Mitsuhiro Inoue, 허지연, Bengt Winblad, Birgitta Wiehager, Lars O. Tjernberg, Natsuko G Yamamoto, Taizo Ishikawa, Takahiro Kihara, Yasuhiro Teranishi , Sophia Schedin-Weiss, Human brain proteins showing neuron-specific interactions with gamma-secretase. , FEBS Journal , Vol.282, No.14, pp. 2587-2599 (4월, 2015)
  • [논문] 허지연, A Dedeoglu, H Li, H Li, H Zheng, H Zhu, I Carreras, M Mwamburi, M Wallack, N Kowall, R Fine, RA Stern, X Sun, X Wang, WQ Qiu, Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer’s disease. , Molecular Psychiatry , Vol.20, No.2, pp. 252-262 (2월, 2015)

연구활동

  • [논문] 허지연, Gamma-secretase in Alzheimers dissease, EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.54, No.4, pp. 433-446 (4월, 2022)
  • [논문] 허지연, Innate immunity protein IFITM3 in Alzheimer’s disease., DNA AND CELL BIOLOGY, pp. 1351-1355 (11월, 2021)
  • [논문] 허지연, Georgia R. Frost, Alan E. Renton, Alison Goate, Andrew McKenzie, Bianca T. Esposito, Bin Zhang, Chen Ming, Christina Crump, Douglas S. Johnson, Eitan Wong, Eliezer Masliah, Ivy Trinh, Jen Chyong Wang, Julia TCW, Ketherine R. Sadleir, Lei Guo, Marilia Barros, Minghui Wang, Paul Greengard, Pengju Nie, Robert A. Rissman, Robert Vassar, Si Jia Pan, Thomas Li, Xianxiao Zhou, Xianzhong Wu, Yong Kim, Yotam Sagi, Yujia Zhai, Yue-Ming Li, The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer’s disease. , Nature, Vol.586, No.7831, pp. 735-740 (10월, 2020)
  • [논문] Mitsuhiro Inoue, 허지연, Bengt Winblad, Birgitta Wiehager, Lars O. Tjernberg, Natsuko G Yamamoto, Taizo Ishikawa, Takahiro Kihara, Yasuhiro Teranishi , Sophia Schedin-Weiss, Human brain proteins showing neuron-specific interactions with gamma-secretase. , FEBS Journal , Vol.282, No.14, pp. 2587-2599 (4월, 2015)
  • [논문] 허지연, A Dedeoglu, H Li, H Li, H Zheng, H Zhu, I Carreras, M Mwamburi, M Wallack, N Kowall, R Fine, RA Stern, X Sun, X Wang, WQ Qiu, Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer’s disease. , Molecular Psychiatry , Vol.20, No.2, pp. 252-262 (2월, 2015)
  • [논문] Hongmei Li, Qinxi Guo, 허지연, Allysa L. Cole, Yueming Li, H Zheng, Modeling Alzheimer’s disease in mouse without mutant protein overexpression: Cooperative and independent effects of Aβ and Tau. , PLoS ONE , Vol.8, No.11, pp. e80706-e80706 (11월, 2013)
  • [논문] Yasuhiro Teranishi, 허지연, Bengt Winblad, Gucci Jijuan Gu, Homira Behbahani, Masood Kamali-Moghaddam, Susanne Frykman, Taizo Ishikawa, Takahiro Kihara, Takeshi Nishimura, Lars O. Tjernberg, Erlin-2 is associated with active gamma-secretase in brain and affects amyloid β-peptide production., Biochemical and Biophysical Research Communications , Vol.424, No.3, pp. 476-481 (8월, 2012)
  • [논문] 허지연, Anna Sandebring, Bengt Winblad, Lars O. Tjernberg, Maria Ancarcrona, Natsuko Goto Yamamoto, Nenad Bogdanovic, Sophia Schedin-Weiss, Takahiro Kihara, Takeshi Nishimura, Yasuhiro Teranishi, Susanne Frykman, Identification of two novel synaptic gamma-secretase associatd proteins that affect amyloid beta-peptide levels without altering Notch processing. , NEUROCHEMISTRY INTERNATIONAL, Vol.61, No.1, pp. 108-118 (4월, 2012)
  • [논문] Natsuko Goto Yamamoto, Bengt Winblad, Lars O Tjernberg, Masakazu Hashimoto, Mitsuhiro Inoue, Susanne Frykman, Takahiro Kihara, Waltteri Hosia, Yasuhiro Teranishi, 허지연, Identification of novel gamma-secretase-associated proteins in detergent-resistant membranes from brain., JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.287, No.15, pp. 11991-12005 (4월, 2012)
  • [논문] Yasuhiro Teranishi, 허지연, Bengt Winblad, Hedvig Welander, Jenny Frånberg, Mikio Aoki, Susanne Frykman, Lars O. Tjernberg, Affinity pulldown of gamma-secretase and associated proteins from human and rat brain. , Journal of Cellular and Molecular Medicine , Vol.14, No.11, pp. 2675-2686 (11월, 2010)
  • [논문] 허지연, Bengt Winblad, Homira Behbahani, Jarmila Nahalkova, Jenny Frånberg, Lars O. Tjernberg, Mikio Aoki, Susanne Frykman, Synaptic and endosomal localization of active gamma-secretase in rat brain. , PLoS ONE , Vol.5, No.1, pp. e8948-e8948 (1월, 2010)
  • [논문] 허지연, Bengt Winblad, Hedvig Welander, Homira Behbahani, Jenny Frånberg, Mikio Aoki, Susanne Frykman, Lars O. Tjernberg, Active gamma-secretase is localized to detergent-resistantmembranes in human brain., FEBS Journal, Vol.275, No.6, pp. 1174-1187 (3월, 2008)
  • [논문] 소정온, 송미숙, 심혜진, 이필휴, 주인수, 허지연, 김영호, 김종원, 나덕렬, 박문호, 정선주, 묵인희, 알쯔하이머병 환자 혈청에서의 베타 아밀로이드 단백질에 대한 특이 항체량 측정: 알쯔하이머병의 생화학적 진단지표 개발, Dementia and Neurocognitive Disorders, Vol.3, No.1, pp. 37-41 (1월, 2004)
  • [학술회의] 허지연, The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer’s disease., The 15th International Conference on Alzheimer’s & Parkinson’s Diseases. , (3월, 2021)
  • [학술회의] 허지연, Y. Li, A. Goate, A. McKenzie, B. Zhang, C. Crump, D. Johnson, E. Masliah, G. R. Frost, J. TCW, J. Wang, K. R. Sadleir, P. Greengard, R. Rissman, R. Vassar, S. Pan, X. Wu, Y. Sagi, Innate immune system modulates gamma-secretase with aging and in Alzheimer’s disease. , Society for Neuroscience 48th Annual Meeting, (11월, 2018)
  • [학술회의] 허지연, Bengt Winblad, Hedvig Welander, Lars O. Tjernberg, Masakazu Hashimoto, Susanne Frykman, Waltteri Hosia, Yasuhiro Teranishi, Gamma-Secretase associated proteins in detergent resistant membranes from brain., 13th International Conference on Alzheimer’s Disease and Related Disorders. , (7월, 2010)
  • [학술회의] 허지연, Active gamma-secretase is localized to detergent resistant membranes in human brain., 11th International Conference on Alzheimer’s Disease and Related Disorders. , (7월, 2008)
  • [학술회의] 허지연, The modulation of gamma-secretase in Alzheimer’s disease, 2022 제39차 한국노화학회 추계학술대회, (12월, 2022)
  • [학술회의] 허지연, Innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer’s disease., 한국노화학회 춘계학술대회, (6월, 2021)
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