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생명과학

대학자연과학대학생명과학과

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이창한Lee, Changhan

  • 소속 생명과학과
  • 연구실원천관 202호
  • 이메일 leec@ajou.ac.kr
  • 내선번호2621

관심분야

  • 미생물 유전학 및 유전체학, 단백질 항상성, 생화학

학력

  • 2012.08 한국과학기술원 박사
  • 2007.02 한국과학기술원 학사

경력

    2021–현재: 아주대학교, 생명과학과, 조교수
2017–2020: University of Michigan, Howard Hughes Medical Institute (미국), 박사후연구원
2015: Heidelberg University (독일), 방문연구원 
2013–2017: Karolinska Institute (스웨덴), 박사후연구원
2012–2013: KAIST, 박사후연구원

연구분야

    단백질은 모든 생명현상에 직접적으로 관여하여 하기 때문에 세균 부터 사람에 이르기까지 모든 생명체의 생명유지에 필수적인 요소이다. 단백질은 외부 혹은 세포 내 다양한 스트레스로 부터 쉽게 변성 된다. 따라서 생명체는 정교한 샤페론 (chaperone) 시스템을 통하여 세포 내의 단백질을 보호하고 항상성을 유지한다. 본 연구실은 감염성 세균과 공생 세균에서 단백질 항상성 시스템을 단백질 안정성 센서, 유전학, 유전체적 기법을 이용하여 동정하고, 이를 통해 발굴된 샤페론 단백질의 분자적 기작을 유전학적, 생화학적으로 규명하는 것을 목표로 한다. 궁극적으로 본 연구를 통한 확립된 지식을 바탕으로, 단백질 항상성 시스템을 타겟으로한 세균의 생장과 감염성을 조절할 수 있는 물질 탐색과 기술개발을 수행하고자 한다.

대표논문

  • [논문] 김현희, Kevin Wu, 이창한, Stress-Responsive Periplasmic Chaperones in Bacteria, FRONTIERS IN MOLECULAR BIOSCIENCES, pp. 1-14 (5월, 2021)
  • [논문] 이창한, Jens Klockgether, Sebastian Fischer, Burkhard Tümmler , Janja Trcek, Ute Römling, Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C, FEMS MICROBIOLOGY REVIEWS, Vol.4, No.66, pp. 740-762 (11월, 2020)
  • [논문] 이창한, Dawid S Zyla, Kevin Wu, Patrick Betschinger, Rudi Glockshuber, James Bardwell, A metabolite binding protein moonlights as a bile-responsive chaperone., EMBO JOURNAL, pp. e104231-e104231 (10월, 2020)
  • [논문] Kevin Wu, 이창한, Frederick Stull, James Bardwell, Protein folding while chaperone bound is dependent on weak interactions, NATURE COMMUNICATIONS, pp. 4833-4842 (10월, 2019)
  • [논문] 이창한, 김현희, Axel Mogk, Bernd Bukau, Heinrich Lünsdorf, Janja Trček, Jasmin Jäger, Kamila B. Franke, Lothar Jänsch, Manfred Nimtz, Shady Mansour Kamal, Ute Römling, Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 273-282 (1월, 2018)

연구활동

  • [논문] Bernd Simon, Panagiotis Katikaridis, Timo Jenne, 문성준, 이창한, Janosch Hennig, Axel Mogk, Structural basis of aggregate binding by the AAA+ disaggregase ClpG, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.11, pp. 105336-105336 (11월, 2023)
  • [논문] 함수정, 이창한, Exploring the impact of nucleic acids on protein stability in bacterialcell lysate , BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, pp. 130445-130445 (8월, 2023)
  • [논문] 구희찬, 문성준, 정주원, 함수정, 김현희, 이창한, Temperature matters: bacterial response to temperature change, JOURNAL OF MICROBIOLOGY, pp. 343-357 (4월, 2023)
  • [논문] 김상하, 이창한, Optimization of transposon mutagenesis methods in Pseudomonas antarctica , Microorganisms, Vol.11, pp. 118-118 (1월, 2023)
  • [논문] 김현희, 정주원, 이창한, A method to study α-synuclein toxicity and aggregation using a humanized yeast model, Jove-Journal of Visualized Experiments, Vol.189, pp. e64418-e64418 (11월, 2022)
  • [논문] 김현희, 문성준, 함수정, Ute Romling, 이기현, 이창한, Cytoplasmic molecular chaperones in Pseudomonas species., JOURNAL OF MICROBIOLOGY, Vol.60, pp. 1049-1060 (11월, 2022)
  • [논문] Kevin Wu, Rishav Mitra, 이창한, James Bardwell, ATP-Independent Chaperones, ANNUAL REVIEW OF BIOPHYSICS, Vol.9, No.51, pp. 409-429 (5월, 2022)
  • [논문] 김현희, Kevin Wu, 이창한, Stress-Responsive Periplasmic Chaperones in Bacteria, FRONTIERS IN MOLECULAR BIOSCIENCES, pp. 1-14 (5월, 2021)
  • [논문] Shady Mansour Kamal, 이창한, Alberto J Martín-Rodríguez, Annika Cimdins-Ahne, Axel Mogk, Fengyang Li, Haleluya Tesfaye Wami , Heinrich Lünsdorf, Lena Meins, Panagiotis Katikaridis, Robert Afasizhev, Ulrich Dobrindt, Zaira Seferbekova, Ute Römling, A recently isolated human commensal Escherichia coli ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage-derived IncY plasmid, MOLECULAR MICROBIOLOGY, pp. 255-271 (2월, 2021)
  • [논문] 이창한, Jens Klockgether, Sebastian Fischer, Burkhard Tümmler , Janja Trcek, Ute Römling, Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C, FEMS MICROBIOLOGY REVIEWS, Vol.4, No.66, pp. 740-762 (11월, 2020)
  • [논문] 이창한, Dawid S Zyla, Kevin Wu, Patrick Betschinger, Rudi Glockshuber, James Bardwell, A metabolite binding protein moonlights as a bile-responsive chaperone., EMBO JOURNAL, pp. e104231-e104231 (10월, 2020)
  • [논문] Ying Liu, 이창한, Alexey Chernobrovkin, Chun-Chi Chen, Fengyang Li, Heike Bähre, Janja Trček, Rey-Ting Guo, Roman Zubarev, Ute Römling, A Cyclic di-GMP Network Is Present in Gram-Positive Streptococcus and Gram-Negative Proteus Species, ACS INFECTIOUS DISEASES, pp. 2672-2687 (10월, 2020)
  • [논문] Kevin Wu, 이창한, Frederick Stull, James Bardwell, Protein folding while chaperone bound is dependent on weak interactions, NATURE COMMUNICATIONS, pp. 4833-4842 (10월, 2019)
  • [논문] Shady Mansour Kamal, 이창한, Christian Giske, Janja Trček, Julien Deschamps, Lothar Jänsch, Luciana Dini, Manfred Nimtz, Morten Levin Rybtke, Romain Briandet, Stefanie Sperlein, Tim Tolker-Nielsen, Ute Römling, Two FtsH Proteases Contribute to Fitness and Adaptation of Pseudomonas aeruginosa Clone C Strains, FRONTIERS IN MICROBIOLOGY, pp. 1372-1381 (7월, 2019)
  • [논문] 이창한, Shady Mansour Kamal, Ute Römling, High frequency of double crossover recombination facilitates genome engineering in Pseudomonas aeruginosa PA14 and clone C strains, MICROBIOLOGY-SGM, pp. 757-760 (7월, 2019)
  • [논문] 이창한, 김현희, James Bardwell, Electrostatic interactions are important for chaperone–client interaction in vivo, MICROBIOLOGY-SGM, pp. 992-997 (7월, 2018)
  • [논문] 이창한, 김현희, Axel Mogk, Bernd Bukau, Heinrich Lünsdorf, Janja Trček, Jasmin Jäger, Kamila B. Franke, Lothar Jänsch, Manfred Nimtz, Shady Mansour Kamal, Ute Römling, Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 273-282 (1월, 2018)
  • [논문] 이창한, 박찬규, Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic Species, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, pp. 169-180 (1월, 2017)
  • [논문] 이창한, 고창민, 권민석, 김도윤, 김동규, 김성훈, 김지연, 김지홍, 민혜영, 이기현, 이나영, 박찬규, Screening for Escherichia coli K-12 genes conferring glyoxal resistance or sensitivity by transposon insertions, FEMS MICROBIOLOGY LETTERS, pp. 363-370 (8월, 2016)
  • [논문] 이창한, EdvardWigren, HeinrichLünsdorf, Ute Römling, Protein homeostasis-more than resisting a hot bath., CURRENT OPINION IN MICROBIOLOGY, pp. 147-154 (4월, 2016)
  • [논문] 이창한, 이정훈, 이주영, 박찬규, Characterization of the Escherichia coli YajL, YhbO and ElbB glyoxalases, FEMS MICROBIOLOGY LETTERS, pp. 363-369 (2월, 2016)
  • [논문] 이창한, Edvard Wigren, Heinrich Lunsdorf, Janja Trcek, Manfred Nimtz, Muhammad Sharif Hasni, Ute Curth, Verena Peters, Ylva Lindqvist, 김지홍, 박찬규, Ute Römling, A novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributed Pseudomonas aeruginosa clone C strains., ENVIRONMENTAL MICROBIOLOGY, Vol.17, No.11, pp. 4511-4526 (11월, 2015)
  • [논문] 이창한, Ojar Melefors, Verena Peters, Ute Römling, Draft Genome Sequence of Pseudomonas aeruginosa SG17M, an Environmental Isolate Belonging to Clone C, Prevalent in Patients and Aquatic Habitats. , GENOME ANNOUNCEMENTS, Vol.2, No.2, pp. 1-2 (3월, 2014)
  • [논문] 이창한, 김인숙, 박찬규, Glyoxal detoxification in Escherichia coli K-12 by NADPH dependent aldo-keto reductases. , JOURNAL OF MICROBIOLOGY, Vol.51, No.4, pp. 527-530 (8월, 2013)
  • [논문] 이창한, 박찬규, 신종철, Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12., MOLECULAR MICROBIOLOGY, Vol.88, No.2, pp. 395-412 (4월, 2013)
  • [논문] 이창한, 박찬규, Mutations upregulating the flhDC operon of Escherichia coli K-12. , JOURNAL OF MICROBIOLOGY, Vol.51, No.1, pp. 140-144 (2월, 2013)
  • [논문] 이창한, 박찬규, Development of a suicidal vector-cloning system based on butanal susceptibility due to an expression of YqhD aldehyde reductase. , JOURNAL OF MICROBIOLOGY, Vol.50, No.2, pp. 249-255 (4월, 2012)
  • [논문] 권민석, 이창한, 이정훈, 박찬규, Genomic rearrangements leading to overexpression of aldo-keto reductase YafB of Escherichia coli confer resistance to glyoxal., JOURNAL OF BACTERIOLOGY, Vol.194, No.8, pp. 1979-1988 (4월, 2012)
  • [논문] 이창한, 김인숙, 민범찬, 이강록, 이정훈, 박찬규, Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12., JOURNAL OF BACTERIOLOGY, Vol.192, No.16, pp. 4205-4214 (8월, 2010)
  • [논문] 김인숙, 이창한, 김준호, 민범찬, 박찬규, Screening of genes related to methylglyoxal susceptibility, JOURNAL OF MICROBIOLOGY, pp. 339-343 (8월, 2007)
해당 데이터는 존재하지 않습니다.
  • [학술회의] 함수정, 이창한, 김현희, Characterization of Acid-responsive Molecular Chaperones Encoded in the Bacterial Transmissible Locus for Protein Quality Control, International Meeting of the Microbiological Society of Korea 2023, (10월, 2023)
  • [학술회의] 김현희, 이창한, James Bardwell, Travis Bell, Systematic discovery of genes related to β-lactam resistance in β-lactamase-producing bacteria, International Meeting of the Microbiological Society of Korea 2023, (10월, 2023)
  • [학술회의] 정주원, 이창한, 김현희, The protective chaperone activity of OPE1 in humanized yeast model to study neurodegenerative diseases, International Meeting of the Microbiological Society of Korea 2023, (10월, 2023)
  • [학술회의] 문성준, 이창한, 김현희, Investigation of substrate and interacting proteins of ClpG disaggregase in Pseudomonas aeruginosa, International Meeting of the Microbiological Society of Korea 2023, (10월, 2023)
  • [학술회의] 김성현, 이창한, 구희찬, Investigation of Cold-Adaptation Strategies of Antarctic Pseudomonas Species at Transcriptome and Proteome Levels, International Meeting of the Microbiological Society of Korea 2023, (10월, 2023)
  • [학술회의] 김상하, 이창한, 문성준, Characterization of Hsp100 disaggregating chaperones in Pseudomonas putida, International Meeting of the Microbiological Society of Korea 2023, (10월, 2023)
  • [학술회의] 함수정, 이창한, 김현희, Characterization of Acid-responsive Molecular Chaperones Encoded in the BacterialTransmissible Locus for Protein Quality Control, ICBP 2023 International Conference on Biological Physics, (8월, 2023)
  • [학술회의] 이창한, Oligopeptidase Moonlights as a Molecular Chaperone, ICBP 2023 International Conference on Biological Physics, (8월, 2023)
  • [학술회의] 김상하, 이창한, 문성준, Characterization of Hsp100 Disaggregating Chaperones in Pseudomonas putida, KMB 2023 Annual Meeting and International Symposium, (6월, 2023)
  • [학술회의] 김성현, 이창한, 구희찬, Investigation of Cold-Adaptation Strategies of Psychrophilic Pseudomonas Species, KMB 2023 Annual Meeting and International Symposium, (6월, 2023)
  • [학술회의] 문성준, 이창한, 김현희, Regulatory Mechanism of Diaggregating Chaperone ClpG in Pseudomonas aeruginosa, International Meeting of the Microbiological Society of Korea, (10월, 2022)
  • [학술회의] 이창한, Chaperone discovery, International Meeting of the Microbiological Society of Korea, (10월, 2022)
  • [학술회의] 김현희, 이창한, Discovery of Anti-protein Aggregating Factors in Bacteria, International Meeting of the Microbiological Society of Korea, (10월, 2022)
  • [학술회의] 함수정, 이창한, 김현희, The Role of Chaperones Encoded in the Transmissible Locus for Protein Quality Control, International Meeting of the Microbiological Society of Korea, (10월, 2022)
  • [학술회의] 정주원, 이창한, 김현희, The Anti-aggregation Activity of OPE1 in Humanized Yeast Model to Study Neurodegenerative Diseases, International Meeting of the Microbiological Society of Korea, (10월, 2022)
  • [학술회의] 이창한, Various Chaperoning Elements in Bacteria, 2023 한국미생물학회 생리생화학 심포지움, (8월, 2023)
  • [학술회의] 이창한, Protein folding sensor for studying neurodegenerative diseases, The 19th Protein Metabolism and Target Protein Degradation , (8월, 2022)
해당 데이터는 존재하지 않습니다.