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서성은Sung-Eun Suh

  • 소속 화학과
  • 연구실원천관 216호
  • 이메일 sesuh@ajou.ac.kr
  • 내선번호2603

관심분야

  • 유기화학, 의약화학, 화학생물학

학력

  • 2017.08 Univ Pennsylvania 박사

경력

    2017.09–2021.02 University of Wisconsin–Madison 박사후 연구원

연구분야

    (1) New Synthetic Methodology Development for DNA-Encoded Library (DEL) Synthesis
Enantioretentive Reactions of Chiral Building Blocks for DEL Synthesis

(2) Regio- and Enantioselective Synthesis of Unnatural Amino Acids for Development of Novel Peptide Drugs
Asymmetric Lewis Acid Catalysis for Synthesis of Enantioenriched Unnatural Amino Acids

(3) Development of Immunotherapy Combination Strategies in Triple-Negative Breast Cancer (TNBC) Treatment
Exploiting Drug Repurposing Strategies to Potentiate TNBC Response to PD-1 Immunotherapy

(4) Advancing Electrochemical Materials Towards Attaining Superior Secondary Battery Innovation 
Development of Potential-Tunable, Robust Redox Mediators and Electrolytes for Development of High-Performance Secondary Batteries

대표논문

  • [논문] 서성은, Leah E. Nkulu, Shane W. Krska, Shishi Lin, Shannon S. Stahl, Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas, CHEMICAL SCIENCE, Vol.12, pp. 10380-10387 (7월, 2021)
  • [논문] 서성은, Elen Hernandez, J. Nicholas Betley, Joomyung V. Jun, Mai N. Tran, David M. Chenoweth, A Rapid Synthesis of Nuclear-Staining Small Fluorescent Molecules for Brain Imaging, CELL REPORTS PHYSICAL SCIENCE, Vol.1, No.10, pp. 100227-100227 (10월, 2020)
  • [논문] 서성은, Christopher J. Cramer, Ilia A. Guzei, Mukunda Mandal, Si-Jie Chen, Shannon S. Stahl, Site-Selective Copper-Catalyzed Azidation of Benzylic C−H Bonds, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.142, No.26, pp. 11388-11393 (7월, 2020)
  • [논문] 서성은, K. N. Houk, Shuming Chen, David M. Chenoweth, The mechanism of the triple aryne–tetrazine reaction cascade: theory and experiment, CHEMICAL SCIENCE, Vol.9, No.39, pp. 7688-7693 (8월, 2018)
  • [논문] 서성은, 윤인아, Stephanie A. Barros, David M. Chenoweth, Synthesis of 9-Substituted Triptycene Building Blocks for Solid-Phase Diversification and Nucleic Acid Junction Targeting, ORGANIC LETTERS, Vol.18, No.5, pp. 1096-1099 (2월, 2016)

연구활동

  • [논문] 서성은, Dung L. Golden, Shannon S. Stahl, Radical C(sp3)–H functionalization and cross-coupling reactions, NATURE REVIEWS CHEMISTRY, pp. .-. (5월, 2022)
  • [논문] Jason S. Bates, Sourav Biswas, 서성은, Biswajit Mondal, Mathew R. Johnson, Shannon S. Stahl, Thatcher W. Root, Chemical and Electrochemical O2 Reduction on Earth-Abundant M-N-C Catalysts and Implications for Mediated Electrolysis, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.144, No.2, pp. 922-927 (1월, 2022)
  • [논문] 서성은, Leah E. Nkulu, Shane W. Krska, Shishi Lin, Shannon S. Stahl, Benzylic C–H isocyanation/amine coupling sequence enabling high-throughput synthesis of pharmaceutically relevant ureas, CHEMICAL SCIENCE, Vol.12, pp. 10380-10387 (7월, 2021)
  • [논문] 서성은, Elen Hernandez, J. Nicholas Betley, Joomyung V. Jun, Mai N. Tran, David M. Chenoweth, A Rapid Synthesis of Nuclear-Staining Small Fluorescent Molecules for Brain Imaging, CELL REPORTS PHYSICAL SCIENCE, Vol.1, No.10, pp. 100227-100227 (10월, 2020)
  • [논문] 서성은, Christopher J. Cramer, Ilia A. Guzei, Mukunda Mandal, Si-Jie Chen, Shannon S. Stahl, Site-Selective Copper-Catalyzed Azidation of Benzylic C−H Bonds, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.142, No.26, pp. 11388-11393 (7월, 2020)
  • [논문] James B. Gerken, 서성은, Alexios Stamoulis, Ilia A. Guzei, Nicholas D. Fischer, 김연정, Shannon S. Stahl, Efficient electrochemical synthesis of robust, densely functionalized water soluble quinones, CHEMICAL COMMUNICATIONS, Vol.56, No.8, pp. 1199-1202 (12월, 2019)
  • [논문] 서성은, K. N. Houk, Shuming Chen, David M. Chenoweth, The mechanism of the triple aryne–tetrazine reaction cascade: theory and experiment, CHEMICAL SCIENCE, Vol.9, No.39, pp. 7688-7693 (8월, 2018)
  • [논문] 서성은, David M. Chenoweth, Aryne Compatible Solvents are not Always Innocent, ORGANIC LETTERS, Vol.18, No.16, pp. 4080-4083 (8월, 2016)
  • [논문] Stephanie A. Barros, 서성은, 윤인아, David M. Chenoweth, Bridgehead-Substituted Triptycenes for Discovery of Nucleic Acid Junction Binders, ORGANIC LETTERS, Vol.18, No.10, pp. 2423-2426 (5월, 2016)
  • [논문] 서성은, 윤인아, Stephanie A. Barros, David M. Chenoweth, Synthesis of 9-Substituted Triptycene Building Blocks for Solid-Phase Diversification and Nucleic Acid Junction Targeting, ORGANIC LETTERS, Vol.18, No.5, pp. 1096-1099 (2월, 2016)
  • [논문] 서성은, Stephanie A. Barros, David M. Chenoweth, Triple aryne–tetrazine reaction enabling rapid access to a new class of polyaromatic heterocycles, CHEMICAL SCIENCE, Vol.6, No.9, pp. 5128-5132 (7월, 2015)
  • [논문] 서성은, 박인걸, 임병윤, 조천규, Acid-Catalyzed [3,3]-Sigmatropic Rearrangement of N-Cbz-Diaryl Hydrazide for the Synthesis of N-Cbz-2,2’-Diamino-1,1’-Diaryls, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol.2011, No.3, pp. 455-457 (12월, 2010)
  • [논문] 박인걸, 서성은, 임병윤, 조천규, Aryl Hydrazide beyond as Surrogate of Aryl Hydrazine in the Fischer Indolization: The Synthesis of N-Cbz-Indoles, N-Cbz-Carbazoles, and N,N′-Bis-Cbz-Pyrrolo[2,3-f]indoles, ORGANIC LETTERS, Vol.11, No.23, pp. 5454-5456 (11월, 2009)
해당 데이터는 존재하지 않습니다.
해당 데이터는 존재하지 않습니다.
  • [학술회의] 서성은, Late-Stage C(sp3)–H Functionalization of Pharmaceutically Relevant Benzylic Compounds, 247회 유기화학분과세미나, (12월, 2021)
  • [학술회의] 서성은, Synthesis of Pharmaceutically Valuable Urea Compounds via Benzylic C–H Isocyanation/Amine Coupling Sequence, 제24회 한국유기합성학회 학술대회 및 정기총회, (11월, 2021)
  • [학술회의] 서성은, Cu-Catalyzed Isocyanation of Benzylic C-H Bonds Enabling High Throughput Synthesis of Diverse Pharmaceutically Relevant Ureas, 제 21 회 유기화학분과회 하계워크샵, pp. 39-39 (6월, 2021)
해당 데이터는 존재하지 않습니다.

특허 및 기타

  • [특허] 서성은, 김나영, 최명수, 키랄 보조제를 이용한 고광학순도의 고리형 알렌 전구체 합성 방법, 특허, (출원) (10-2023-0185697) (12월, 2023)
  • [특허] 서성은, 최명수, 황지원, 리튬 공기 이차전지용 전해액 조성물 및 이를 포함하는 리튬 공기 이차전지, 특허, (출원) (10-2023-0186020) (12월, 2023)