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아주대학교 약학대학

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대학약학대학약학과

List

이동주Dongjoo Lee

  • 소속 약학과
  • 연구실혜강관 320호
  • 이메일 dongjoo@ajou.ac.kr / drlee21@gmail.com
  • 내선번호3455

관심분야

  • 천연물 전합성 및 신규 유기합성 반응의 개발

학력

  • 2007.05 PENNSYLVANIA, UNIV. OF 박사
  • 2000.02 서울대학교 석사
  • 1998.02 서울대학교 학사

경력

    2017.03-Present Associate Professor, College of Pharmacy, Ajou University, South Korea
2013.03-2017.02 Assistant Professor, College of Pharmacy, Ajou University, South Korea
2011.03-2013.02 Assistant Professor, College of Pharmacy, Dankook University, South Korea
2007.04-2010.10 Post-Doctoral Fellow, Memorial Sloan-Kettering Cancer Center, NY, USA

연구분야

    1. Development of New Synthetic Transformations and their Application to Total Synthesis of Biologically Active Natural Products
2. Discovery of Novel Therapeutic Agents by a Wide Range of Synthetic Studies of Chemical Probes and Analogues

대표논문

  • [논문] 유희선, 김형수, 이량하, 이동주, Diastereoselective Construction of trans-2-Alkyl-6-aryl-3,6-dihydro-2H-pyrans via Dehydrogenative Cycloetherification Promoted by DDQ, ORGANIC LETTERS, Vol.23, No.3, pp. 1135-1140 (2월, 2021)
  • [논문] 조민미, 이동주, 곽영신, Rapid Access to the Structural Core of Aflavinines via Stereoselective Tandem intramolecular Diels-Alder Cycloaddition Controlled by the Allylic 1,3-Strain, ORGANIC LETTERS, Vol.21, No.16, pp. 6529-6533 (8월, 2019)
  • [논문] 유희선, 김형수, 이량하, 이동주, Lewis Acid-Promoted Regio- and Diastereoselective Cross-Coupling of Aryl-Substituted 1,2-Diols and Boronic Acids, JOURNAL OF ORGANIC CHEMISTRY, Vol.84, No.6, pp. 3566-3578 (3월, 2019)
  • [논문] 김형수, 이동주, A Concise Formal Total Synthesis of (±)-Centrolobine via DDQ-Mediated Diastereoselective Allylation and Ring-Closing Metathesis, SYNLETT, Vol.26, No.18, pp. 2583-2587 (9월, 2015)
  • [논문] Arun Naini, 이동주, Amos B. Smith, III, Aruna Raja, Florenz Sasse, Ian Harrier, Raimo Franke, Richard E. Taylor, Yazh Muthukumar, Markus Kalesse, The Synthesis and Biological Evaluation of Desepoxyisotedanolide and a Comparison with Desepoxytedanolide, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol.54, No.23, pp. 6935-6939 (6월, 2015)

연구활동

  • [논문] 안병연, 이량하, 김형수, 이동주, Concise Stereoselective Total Synthesis of (-)-Hedycoropyran A, JOURNAL OF ORGANIC CHEMISTRY, Vol.88, No.24, pp. 17172-17180 (12월, 2023)
  • [논문] 곽수연, 신일진, 박영직, 이동주, 임성주, 김득준, 장홍준, 김형수, Stereoselective total synthesis of (3Z)- and (3E)-elatenynes, RSC Advances, pp. 35920-35925 (12월, 2023)
  • [논문] 곽수연, 박영직, 이동주, 임성주, 장홍준, 김득준, 김형수, Total Synthesis and Structure Confirmation of (−)-Asimitrin,a C37 Annonaceous Acetogenin with a Hydroxylated Adjacent Bis-Tetrahydrofuran Core, ORGANIC LETTERS, pp. 6659-6664 (8월, 2023)
  • [논문] 신일진, 곽수연, 박영직, 이동주, 장홍준, 김득준, 김형수, Highly Stereodivergent Construction of a C2‑Symmetric cis,cis- andtrans,trans-2,6-Dioxabicyclo[3.3.0]octane Framework by DoubleIntramolecular Amide Enolate Alkylation: Total Synthesis of(+)-Laurenidificin and (+)-Aplysiallene, ORGANIC LETTERS, pp. 0000-0000 (11월, 2022)
  • [논문] 김태우, 김현수, 김동준, 이종국, 장재봉, 이동주, 김석호, Synthesis of 7,2'-Dihydroxy-4',5'-Dimethoxyisoflavanone, a Phytoestrogen with Derma Papilla Cell Proliferative Activity, MOLECULES, pp. 6660-6660 (10월, 2022)
  • [논문] 이동주, 이지훈, 이철행, 임동유, 전지현, 송임숙, 최민구, Development of Jaspine B analysis using LC-MS/MS and its application: Dose-independent pharmacokinetics of Jaspine B in rats, ANALYTICAL SCIENCE & TECHNOLOGY, Vol.34, No.2, pp. 37-45 (4월, 2021)
  • [논문] 장홍준, 곽수연, 이동주, Juan V. Alegre-Requena, Robert S. Paton, 김득준, 김형수, Asymmetric Total Synthesis and Determination of the Absolute Configuration of (+)-Srilankenyne via Sequence-Sensitive Halogenations Guided by Conformational Analysis., ORGANIC LETTERS, Vol.23, No.4, pp. 1321-1326 (2월, 2021)
  • [논문] 유희선, 김형수, 이량하, 이동주, Diastereoselective Construction of trans-2-Alkyl-6-aryl-3,6-dihydro-2H-pyrans via Dehydrogenative Cycloetherification Promoted by DDQ, ORGANIC LETTERS, Vol.23, No.3, pp. 1135-1140 (2월, 2021)
  • [논문] 유희선, 김형수, 백승훈, 이동주, Direct and Efficient C(sp3)-H Functionalization of N-Acyl/Sulfonyl Tetrahydroisoquinolines (THIQs) With Electron-Rich Nucleophiles via 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ) Oxidation, FRONTIERS IN CHEMISTRY, pp. 629-629 (7월, 2020)
  • [논문] 조민미, 이동주, 곽영신, Rapid Access to the Structural Core of Aflavinines via Stereoselective Tandem intramolecular Diels-Alder Cycloaddition Controlled by the Allylic 1,3-Strain, ORGANIC LETTERS, Vol.21, No.16, pp. 6529-6533 (8월, 2019)
  • [논문] 정혜경, 김홍표, 이동주, 백승훈, Structure analysis and antioxidant activities of an amylopectin-typepolysaccharide isolated from dried fruits of Terminalia chebula, CARBOHYDRATE POLYMERS, pp. 100-108 (5월, 2019)
  • [논문] 유희선, 김형수, 이량하, 이동주, Lewis Acid-Promoted Regio- and Diastereoselective Cross-Coupling of Aryl-Substituted 1,2-Diols and Boronic Acids, JOURNAL OF ORGANIC CHEMISTRY, Vol.84, No.6, pp. 3566-3578 (3월, 2019)
  • [논문] 서민지, 김인영, 이동민, 이동주, 박석순, 이주연, 정성윤, 최민구, 최은경, 최경숙, Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis, CELL DEATH & DISEASE, Vol.10, No.3, pp. 187-203 (2월, 2019)
  • [논문] 김홍표, 유희선, 김형수, 이동주, 김석호, DDQ-Promoted Mild and Efficient Metal-Free Oxidative α-Cyanation of N-Acyl/Sulfonyl 1,2,3,4-Tetrahydroisoquinolines, MOLECULES, Vol.23, No.12, pp. 3223-3235 (12월, 2018)
  • [논문] 이동민, 박석순, 김환명, 박상준, 손성향, 윤계순, 이동주, 임준희, 엄용우, 정성윤, 최은경, 최경숙, Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis, CARCINOGENESIS, Vol.1, No.1, pp. 1-13 (1월, 2018)
  • [논문] 권미리, 김인영, 서민지, 이동민, 이동주, 최민구, 최경숙, Ohiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis, ONCOTARGET, pp. 106740-106752 (12월, 2017)
  • [논문] 최민구, 이동주, 강윤주, 권미화, 남소정, 이지훈, 최광식, 최영아, 한유진, 송임숙, Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats, MARINE DRUGS, pp. 279-295 (9월, 2017)
  • [논문] 이기연, 권혁래, 신일진, 장홍준, 서재홍, 김형수, 이동주, Total Synthesis of (±)-Decytospolides A and B, SYNLETT, Vol.2, pp. 249-252 (1월, 2017)
  • [논문] 신일진, 김형수, 이동주, Substrate-Controlled Asymmetric Total Synthesis and Structure Revision of (?)-Bisezakyne A, ORGANIC LETTERS, Vol.18, No.17, pp. 4420-4423 (8월, 2016)
  • [논문] 이동주, SAHA SHARMISTHA, 김인영, 최경숙, Paraptosis in the anti-cancer arsenal of natural products, PHARMACOLOGY & THERAPEUTICS, Vol.162, pp. 120-133 (6월, 2016)
  • [논문] 신일진, 장홍준, 이동주, 김득준, 김형수, Stereoselective Substrate-Controlled Asymmetric Syntheses of both 2,5-cis- and 2,5-trans-Tetrahydrofuranoid Oxylipids: Stereodivergent Intramolecular Amide Enolate Alkylation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, pp. 6497-6501 (5월, 2016)
  • [논문] 김형수, 이동주, A Concise Formal Total Synthesis of (±)-Centrolobine via DDQ-Mediated Diastereoselective Allylation and Ring-Closing Metathesis, SYNLETT, Vol.26, No.18, pp. 2583-2587 (9월, 2015)
  • [논문] 김규동, 이동주, Pramod K. Sahu, Shuhao Qu, 유진하, 최유진, 정낙신, Stereoselective Synthesis of D-5-Homo-4-Selenoribose as a Versatile Intermediate for 4'-Selenonucleosides, ORGANIC LETTERS, Vol.17, No.18, pp. 4636-4639 (9월, 2015)
  • [논문] Arun Naini, 이동주, Amos B. Smith, III, Aruna Raja, Florenz Sasse, Ian Harrier, Raimo Franke, Richard E. Taylor, Yazh Muthukumar, Markus Kalesse, The Synthesis and Biological Evaluation of Desepoxyisotedanolide and a Comparison with Desepoxytedanolide, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol.54, No.23, pp. 6935-6939 (6월, 2015)
  • [논문] 이동주, 고은재, 신일진, 서승용, 이기연, 김형수, Total Synthesis of Acetylcholinesterase Inhibitor Macakurzin C, SYNLETT, Vol.25, No.19, pp. 2794-2796 (12월, 2014)
  • [논문] 이동주, 신일진, 황윤정, 서승용, 이기연, 김형수, Concise and stereoselective synthesis of (±)-Hagen's gland lactone, RSC ADVANCES, Vol.4, pp. 52637-52639 (10월, 2014)
  • [논문] 임동희, 신일진, 김형수, 이동주, Gram-scale synthesis of anti-pancreatic flavonoids (±)-8-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]-chrysin and -galangin, TETRAHEDRON, Vol.70, No.32, pp. 4738-4744 (8월, 2014)
  • [논문] 배훈, 백동재, 전홍준, 이동주, 김상희, Stereochemically Reliable Syntheses of Pachastrissamine and Its 2-epi-Congener via Oxazolidinone Precursors from an Established Starting Material N-tert-butoxycarbonyl-Protected Phytosphingosine, SYNTHESIS-STUTTGART, pp. 3609-3612 (12월, 2012)
  • [논문] 이동주, A Concise Total Synthesis of 2-epi-(-)-Pachastrissamine via a Three-Component Tandem Cross-Metathesis-Intramolecular SN2' Substitution-Cross-Metathesis Sequence, SYNLETT, pp. 2840-2844 (12월, 2012)
  • [논문] 이지훈, 이동주, 권미화, 최광익, 최민구, 송임숙, Differential Cytotoxic Effects of Jaspine B in Various Cancer Cells, 생명과학회지, Vol.26, No.12, pp. 1392-1399 (12월, 2016)
  • [학술회의] 김민영, 백승훈, 유희선, 이동주, 고현정, 송재형, Structure analysis of pectic polysaccharides isolated from the root of Sanguisorba officinalis, 2022 대한약학회 추계국제학술대회, pp. 835- (10월, 2022)
  • [학술회의] 이찬양, 백승훈, 김영훈, 김형수, 문정주, 이동주, Development and uncertainty estimation of bifenazate certified reference material using mass balance method, 2022 대한약학회 추계국제학술대회, pp. 683- (10월, 2022)
  • [학술회의] 이찬양, 백승훈, 김영훈, 김형수, 문정주, 이동주, Development and uncertainty estimation of acynonapyr certified reference material using mass balance method, 2022 대한약학회 추계국제학술대회, (10월, 2022)
  • [학술회의] 이찬양, 백승훈, 김영훈, 김형수, 문정주, 이동주, Development and uncertainty estimation of flometoquin certified reference material using mass balance method, 2022 대한약학회 추계국제학술대회, pp. 684- (10월, 2022)
  • [학술회의] 이동주, Asymmetric Stereoselective Total Synthesis of trans-2-Aryl-6-alkyl-tetrahydro-2H-pyran Natural Products, 2022 대한약학회 춘계 국제학술대회 심포지엄, (4월, 2022)
  • [학술회의] 유희선, 이동주, 이종국, 이량하, 황정중, Synthetic Studies of 1,3,5-Dihydrotriazine, 2019 Fall International Convention of Pharmaceutical Society of Korea, (10월, 2019)
  • [학술회의] 유희선, 이동주, A-DDQ-Promoted Diastereoselective Synthesis of Arylated trans-2,6-Disubstituted-3,4-Dihydropyrans, The 12th International Conference on Cutting-Edge Organic Chemistry in Asia/The 3rd Advanced Research Network on Cutting-Edge Organic Chemistry in Asia, (11월, 2017)
  • [학술회의] 이동주, Studies Directed Towards the Total Synthesis of Tetrahydropyranyl Diarylheptanoid Natural Products, The Spring International Convention of the Pharmaceutical Society of Korea, (4월, 2014)
  • [학술회의] 이경진, 김형수, 백승훈, 이동주, 김용준, 김희서, 이희연, Establishment of a certified reference materials of spiropidion and its metabolite spiropidion-enol using mass balance method, 제71회 한국분석과학회 추계 학술대회, (11월, 2023)
  • [학술회의] 이경진, 김형수, 백승훈, 이동주, 김주엽, 이희연, 하태곤, Development of certified reference material of 5-hydroxy imidacloprid using organic synthesis and mass balance method, 제71회 한국분석과학회 추계 학술대회, (11월, 2023)
  • [학술회의] 이찬양, 백승훈, 김영훈, 김형수, 이경진, 이동주, Feasibility study on the thermogravimetric analysis as an alternative to volatile and inorganic impurity assays in mass balance method for certified reference standard, 제10회 대한약학회 약품분석학분과 동계심포지엄 및 정기총회, (1월, 2023)
  • [학술회의] 김영훈, 백승훈, 김형수, 이동주, 이찬양, 이경진, Development of certified reference materials of Isofetamid and GPTC using mass balance method and differential scanning calorimetry, 제69회 한국분석과학회 추계 학술대회, pp. 9- (11월, 2022)
  • [학술회의] 김영훈, 백승훈, 김형수, 이동주, 이찬양, 이경진, Development of certified reference materials of cyclaniliprole using mass balance method and differential scanning calorimetry, 제69회 한국분석과학회 추계 학술대회, pp. 9- (11월, 2022)
  • [학술회의] 김영훈, 백승훈, 김형수, 이동주, 이찬양, 이경진, Development of certified reference materials of Imidacloprid using mass balance method and differential scanning calorimetry, 제69회 한국분석과학회 추계 학술대회, pp. 9- (11월, 2022)
  • [학술회의] 김영훈, 백승훈, 김형수, 이동주, 이찬양, 이경진, Development of certified reference materials of Tiafenacil using mass balance method and differential scanning calorimetry, 제69회 한국분석과학회 추계 학술대회, pp. 9- (11월, 2022)
  • [학술회의] 이동주, Diastereoselective Construction of Arylated Stereogenic Centers and its Application to Total Synthesis of Natural Products, 제25회 한국유기합성학회 학술대회(워크샵), (2월, 2022)
  • [학술회의] 김영훈, 김형수, 백승훈, 이동주, 문정주, 박의정, 손유희, 유희선, 이찬양, 장홍준, 한재혁, Development and certification of bifenazate diazene reference material using mass balance method, 제67회 한국분석과학회 추계 학술대회, (11월, 2021)
  • [학술회의] 유희선, 이동주, 김형수, 백승훈, A General Strategy for the Synthesis of 9-Norneolignans: Enantioselective Total Synthesis of (-)-Agatharesinol, (-)-Agatharesinol Acetonide, (-)-Sugiresinol and ent-(+)-Hinokiresinol, 제17회 대한약학회 약품화학분과학회 워크샵, pp. 53-53 (6월, 2021)
  • [학술회의] 유희선, 이동주, 1,3-Asymmetric Induction of Chiral 3-Substituted Tetrahydroisoquinolines Promoted by DDQ, 제15회 대한약학회 약품화학분과학회 워크샵, (6월, 2019)
  • [학술회의] 이동주, Asymmetric Stereoselective Total Syntheses of (+)-6-epi-Goniothalesdiol A and (+)-Parvistone E, and a Formal Total Synthesis of (-)-8-epi-9-Deoxygoniopypyrone Acetate, 제8회 약품화학워크샵 (Frontiers in Medicinal Chemistry 8th Workshop), (4월, 2019)
  • [학술회의] 유희선, 이동주, Diastereoselective Cross-Coupling of Aryl-Substituted Diol and Boronic Acids Promoted by Lewis Acids, 제14회 대한약학회 약품화학분과학회 워크샵, (6월, 2018)
  • [학술회의] 이량하, 이동주, Stereoselective Total Synthesis of (±)-6-epi-Goniothalesdiol A & (±)-Leiocarpin A, 제14회 대한약학회 약품화학분과학회 워크샵, (6월, 2018)
  • [학술회의] 이동주, Lewis Acid-Promoted Regio- and Diastereoselective Cross-Coupling of Aryl-Substituted Diols with Boronic Acids, 제7회 약품화학워크샵 (Frontiers in Medicinal Chemistry 7th Workshop), (3월, 2018)
  • [학술회의] 이동주, Oxidative Functionalization at the Benzylic Postion and its Application to Natural Product Synthesis, 2017 한국유기합성학회 WORK SHOP, (3월, 2017)
  • [학술회의] 이동주, A diastereoselective Synthesis of Arylated Dihydropyrns Utilizing DDQ-Promoted Oxidative Intramolecular Etherification, 제6회 약품화학워크샵 (Frontiers in Medicinal Chemistry 6th Workshop, (3월, 2017)
  • [저서] 김형수, 이동주, 강원구, 강진양, 곽재환, 김영우, 김은애, 김익연, 김하형, 나영화, 남태규, 마은숙, 민경훈, 박명숙, 박소연, 박애경, 박요한, 박일영, 박해일, 박형근, 백승만, 변영주, 서승용, 서재홍, 송규옹, 신계정, 신동윤, 신동해, 오경택, 오승열, 오현철, 윤구, 이복률, 이상협, 이수재, 이용섭, 이응석, 이종국, 이종현, 장영동, 정영훈, 정종화, 정진현, 정춘식, 최보길, 한영택, 무기 및 방사성 의약품학, (2월, 2013)
  • [저서] 김형수, 이동주, 곽영신, 김남중, 김대기, 김득준, 김상희, 김석호, 김영우, 김은애, 김익연, 김인수, 김학성, 김희두, 나영화, 마은숙, 문형룡, 민경훈, 박명숙, 박민수, 박요한, 박해일, 박현주, 박형근, 박혜영, 백승만, 변영주, 서승용, 서영거, 서영호, 서재홍, 송규용, 신계정, 신동윤, 유재상, 윤구, 이경, 이상협, 이용섭, 이응석, 이종국, 이지연, 이지우, 이태호, 이희순, 임세진, 임채욱, 장영동, 전라옥, 정낙신, 정병선, 정상헌, 정연진, 정영훈, 정재경, 정종화, 정진현, 조원제, 천승훈, 최선, 최원준, 하정미, 하형호, 한영택, 함원훈, 홍준희, 실험의약품합성학, (2월, 2013)

특허 및 기타

  • [특허] 백승훈, 김형수, 이동주, GPTC 제조방법, 특허, (출원) (10-2023-0195621) (12월, 2023)
  • [특허] 백승훈, 김형수, 이동주, GPTC의 대량 합성 방법, 특허, (출원) (10-2023-0001482) (1월, 2023)