약학대학

관심분야

• 점막 면역학 및 감염 대응기전

• Mucosal immunology and host defense

학력

• 2004.02 서울대학교대학원 박사
• 2000.02 서울대학교대학원 석사
• 1998.02 서울대학교 학사

경력

Mar. 2004- Jun. 2004	Post-doctoral fellow	     Seoul National University
Jul. 2004- Nov. 2008	Post-doctoral fellow	     International Vaccine Institute
Dec. 2008- Sep. 2009	Post-doctoral fellow	     Harvard Medical School/BWH
Oct. 2009-Aug. 2010	Post-doctoral fellow	     Harvard Medical School/MGH
Sep. 2010-Feb. 2012     Research Scientist        International Vaccine Institute
Mar. 2012-Present          Professor        College of Pharmacy, Ajou University

연구분야

General interests: “Mucosal Immunology and Host Defense”
We are interested in the immune regulation mechanism observed in the mucosal tissues which is called mucosal immunology. Mucosal tissues including gastrointestinal tract, respiratory tract and urogenital tract were exposed to external environment, colonized commensal microbes and serve as an infection route of pathogen. These tissues have established complex and elegant immune system to regulate immunity via immune tolerance to commensal microbes versus to induce strong protective immunity against invading pathogen. Therefore, mucosal immune system is distinct with sterile systemic immune system and developed their unique system. To reveal the puzzling immunological network in these tissues, we are focused on the study for the function of antigen presenting cell group, especially dendritic cells (DCs). In addition, we also have interests about the cross-talk between sterile systemic and mucosal system under disease condition, dendritic cell conditioning under specialized microenvironments, interaction between commensal microbes and immune system and infectious disease including development of vaccines. 

대표논문

• [논문] 정현진(제1), 홍은혜(제1), Bruce A Vallance, Takao Iwawaki, 구자현, 김채원, 박윤용, 안재희, 양윤미, 윤병일, 정재현, 조재원, 장선영*, 고현정*, ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions, EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.55, No.2, pp. 401-412 (02월, 2023)
• [논문] 김영인(제1), 이은제, 고현정, 김성열, 김영대, 이아름, 정지웅, 조중명, 천재희, 하해찬, 장선영*, 홍용래*, Local stabilization of hypoxia-inducible factor-1 controls intestinal inflammation via enhanced gut barrier function and immune regulation, FRONTIERS IN IMMUNOLOGY, Vol.11, pp. 1-14 (01월, 2021)
• [논문] Joannie M. Allaire(제1), Shauna M. Crowley(제1), 장선영, Hong T. Law, 고현정, Bruce A. Vallance*, The Intestinal Epithelium: Central Coordinator of Mucosal Immunity, TRENDS IN IMMUNOLOGY, Vol.39, No.9, pp. 677-696 (09월, 2018)
• [논문] 김영인(제1), 강창율, 고현정, 권미나, 송주혜, 장선영*, Hans-Christian Reinecker*, CX3CR1+ Macrophages and CD8+ T Cells Control Intestinal IgA Production, JOURNAL OF IMMUNOLOGY, pp. 1287-1294 (06월, 2018)
• [논문] 김민수(제1), 김유진(제1), 양진영(제1), 천재희(제1), 장선영, 고현정, 김범석, 김예지, 배진우, 서상욱, 신승호, 이수현, 이용수, 최선심, 권미나*, Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production, IMMUNITY, Vol.44, No.4, pp. 889-900 (04월, 2016)

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