기초과학 자율운영 중점연구소

생명과학과에서 아래와 같이 세미나를 실시합니다.

많은 관심과 참여 부탁드립니다.

주관: 기초과학연구소(자율운영 중점연구소지원사업)

일시: 2024년 5월 30일 목요일 17:00

장소: 원천관 212호

연사: 김진해 교수(대구경북과학기술원)

주제: Structural perspectives on protein aging and aggregation

Proteins are intrinsically dynamic. Many proteins accommodate structurally-distinctive conformations upon being exposed to different conditions or interacting with various molecules, and understanding to these structural transitions is a key to elucidating the mechanistic details of the protein functions and activities. Notably, the native equilibrium states over diverse structural conformations of proteins are maintained with delicate balance, perturbation of which could shift the original structural equilibrium. Diseases of proteinaceous origins are often caused by this disruption of protein dynamics, and, among various factors, ‘protein aging’ is one of the major culprits that break the dynamic balance of protein structures. This is particularly true for many proteins showing amyloidogenic properties. In this talk, I will present our work exemplifying the direct correlation of structural perturbation of a protein with its pathogenic mechanism. More specifically, I would like to discuss the quaternary dynamics of transthyretin and the related pathogenic processes and its lipid-mediated structural deformation.